Interaction analysis of TcrX/Y two component system from Mycobacterium tuberculosis
نویسندگان
چکیده
منابع مشابه
Two-Component System of Mycobacterium Tuberculosis
Two Component Systems (TCSs), are widespread signal transduction devices in prokaryotes that enable these organisms to elicit an adaptive response to environmental stimuli, primarily through changes in gene expression [1]. They are typically composed of a membrane-located sensor with histidine kinase activity and a cytoplasmic transcriptional regulator. Generally, stimuli detected by TCS autoph...
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The mechanisms utilized by Mycobacterium tuberculosis to establish, maintain, or reactivate from latent infection in the host are largely unknown but likely include genes that mediate adaptation to conditions encountered during persistence. Previously, a two-component signal transduction system, mprAB, was found to be required in M. tuberculosis for establishment and maintenance of persistent i...
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Two-component systems are the major means by which bacteria couple adaptation to environmental changes. All utilize a phosphorylation cascade from a histidine kinase to a response regulator, and some also employ an accessory protein. The system-wide signaling fidelity of two-component systems is based on preferential binding between the signaling proteins. However, information on the interactio...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.709.1